Detailed Analysis of Variation at and around Mitochondrial Position 16189 in a Large Finnish Cohort Reveals No Significant Associations with Early Growth or Metabolic Phenotypes at Age 31 Years

Sreena Das; Amanda J. Bennett; Ulla Sovio; Aimo Ruokonen; Hannu Martikainen; Anneli Pouta; Anna‐Liisa Hartikainen; Stephen Franks; Paul Elliott; Joanna Poulton; Paul M Ridker; Mark I. McCarthy

doi:10.1210/jc.2007-0702

Shared by

Paul M Ridker

Harvard University

Detailed Analysis of Variation at and around Mitochondrial Position 16189 in a Large Finnish Cohort Reveals No Significant Associations with Early Growth or Metabolic Phenotypes at Age 31 Years

Article 2007 en

Authors

SD
Sreena Das
AB
Amanda J. Bennett
US
Ulla Sovio

Abstract

1 min read

Context: Mitochondrial dysfunction is increasingly implicated in pathogenesis of adult metabolic disease. Rare mitochondrial (mt) DNA mutations impair glucose homeostasis, but the contribution of common variants is unclear. In small studies, variation within the OriB origin of replication (at mt16189 in particular) has been associated with both early growth and adult metabolic phenotypes and may contribute to life-course relationships between the two.

Discussion(0)

No comments yet. Be the first to comment.

Detailed Analysis of Variation at and around Mitochondrial Position 16189 in a Large Finnish Cohort Reveals No Significant Associations with Early Growth or Metabolic Phenotypes at Age 31 Years

Abstract

Discussion(0)

Related publications

Variation at the insulin gene VNTR minisatellite is associated with fasting insulin levels at 31 years: analyses from a large Finnish cohort

No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort

No association between placental weight or ratio at birth and risk of atopy, hay fever, or asthma at the age of 31 years.

Early Life Factors and Blood Pressure at Age 31 Years in the 1966 Northern Finland Birth Cohort

Cloninger’s Temperament Dimensions, Socio-economic and Lifestyle Factors and Metabolic Syndrome Markers at Age 31 Years in the Northern Finland Birth Cohort 1966

Related publications

Article2002
Variation at the insulin gene VNTR minisatellite is associated with fasting insulin levels at 31 years: analyses from a large Finnish cohort
Article2002

Article2005
No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort
Article2005

Article2007
No association between placental weight or ratio at birth and risk of atopy, hay fever, or asthma at the age of 31 years.
Article2007

Article2004
Early Life Factors and Blood Pressure at Age 31 Years in the 1966 Northern Finland Birth Cohort
Article2004

Article2007
Cloninger’s Temperament Dimensions, Socio-economic and Lifestyle Factors and Metabolic Syndrome Markers at Age 31 Years in the Northern Finland Birth Cohort 1966
Article2007