Design and Synthesis of Regioisomeric Analogues of a Specific Anti-HIV-1 Agent 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

Hiromichi Tanaka; Masanori Baba; Emiko Takahashi; Kouichiro Matsumoto; Atsushi Kittaka; Richard Walker; De Clercq Erik; Tadashi Miyasaka

doi:10.1080/15257779408013232

Abstract

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Abstract Regioisomeric analogues of the anti-HIV-1 lead 1-[(2-hydroxy-ethoxy)methyl]-6-(phenylthio)thymine (1: HEPT) have been synthesized. These compounds, having an ethoxymethyl side chain at C-5 and an ethyl group at the N-1 position of the uracil ring, also possess activity against HIV-1.

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