Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Julián Aragonés; Martin Schneider; Katie Van Geyte; Peter Fraisl; Tom Dresselaers; Massimiliano Mazzone; Ruud Dirkx; Serena Zacchigna; Hélène Lemieux; Nam Ho Jeoung; Diether Lambrechts; Tammie Bishop; Peggy Lafuste; Antonio Dı́ez-Juan; Sarah K. Harten; Pieter Van Noten; Katrien De Bock; Carsten Willam; Marc Tjwa; Alexandra Grosfeld; Rachel Navet; Lieve Moons; Thierry VandenDriessche; Christophe M. Deroose; Bhathiya Wijeyekoon; Johan Nuyts; Bénédicte F. Jordan; Robert Silasi‐Mansat; Florea Lupu; Mieke Dewerchin; Christopher W. Pugh; Phil Salmon; Luc Mortelmans; Bernard Gallez; Frans Gorus; Johan Buyse; Francis Sluse; R. Adron Harris; Erich Gnaiger; Peter Hespel; Paul Van Hecke; Frans Schuit; Paul Van Veldhoven; Peter J. Ratcliffe; Myriam Baes; Patrick H. Maxwell; Peter Carmeliet

doi:10.1038/ng.2007.62

Related publications

Article2008

Hypoxia tolerance induced by deficiency of the oxygen sensor PHD1: study of the basel metabolism by MR Spectroscopy

Tom Dresselaers, Julián Aragonés, Michael Schneider, Katie Van Geyte, Peter Fraisl, P H Maxwell, Peter Carmeliet, Uwe Himmelreich

Article2016

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism

Annelies Quaegebeur, Inmaculada Segura, Roberta Schmieder, Dries Verdegem, Ilaria Decimo, Francesco Bifari, Tom Dresselaers, Guy Eelen, Debapriya Ghosh, Shawn M. Davidson, Sandra Schoors, Dorien Broekaert, Bert Cruys, Kristof Govaerts, Carla De Legher, Ann Bouché, Luc Schoonjans, Matt S. Ramer, Gene Hung, Goele Bossaert, Don W. Cleveland, Uwe Himmelreich, Thomas Voets, Robin Lemmens, C. Frank Bennett, Wim Robberecht, Katrien De Bock, Mieke Dewerchin, Bart Ghesquière, Sarah‐Maria Fendt, Peter Carmeliet

Article2008

Heterozygous deficiency of the oxygen sensor PHD2 prevents metastasis by inducing vessel normalization

Daniela Dettori, Max Mazzone, Rodrigo Leite-de-Oliveira, Julián Aragonés, Bart Jonckx, Aernout Luttun, Stefan Vinckier, Bénédicte F. Jordan, Bernard Gallez, Peter Carmeliet

Article2017

Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism

A. A. Roger Thompson, Rebecca Dickinson, Fiona Murphy, John P. Thomson, Helen M. Marriott, Adriana Tavares, Joseph Willson, Lynne Williams, Amy Lewis, Ananda S. Mirchandani, Patricia Dos Santos Coelho, Catherine Doherty, Eilíse M. Ryan, Emily Watts, Nicholas M. Morton, Shareen Forbes, Roland H. Stimson, Abdul Hameed, Nadine Arnold, Julie A. Preston, Allan Lawrie, Veronica Finisguerra, Massimiliano Mazzone,

Preprint2024

Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function

Emily Watts, Joseph Willison, Simone Arienti, Pranvera Sadiku, Patrícia Coelho, Manuel A. Sánchez-García, Ailiang Zhang, Fiona Murphy, Rebecca Dickinson, Ananda S. Mirchandani, Tyler Morrison, Amy Lewis, Wesley Vermaelen, Bart Ghesquière, Peter Carmeliet, Massimiliano Mazzone, Patrick H. Maxwell, Christopher W. Pugh, David H. Dockrell, Moira K. B. Whyte, Sarah R. Walmsley