Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia

Elke Marsch; Jasper A. F. Demandt; Thomas Theelen; Bibian M. E. Tullemans; Kristiaan Wouters; Mariëtte R. Boon; Theo H. van Dijk; Marion J. Gijbels; Ludwig J. Dubois; Steven J.R. Meex; Massimiliano Mazzone; Gene Hung; Edward A. Fisher; Erik A.L. Biessen; Mat J.A.P. Daemen; Patrick C.N. Rensen; Peter Carmeliet; Albert K. Groen; Judith C. Sluimer

doi:10.1093/eurheartj/ehw156

Abstract

1 min read

Overall, PHD1 knockout mice display a metabolic phenotype that generally is deemed protective for cardiovascular disease. Future studies should focus on the efficacy, safety, and gender-specific effects of PHD1 inhibition in humans, and unravel the molecular actors responsible for PHD1-driven, likely intestinal, and regulation of cholesterol metabolism.

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