Defect of Adaptation to Hypoxia in Patients With COPD Due to Reduction of Histone Deacetylase 7
Article 2011 en
Authors
MT
Masako To
SY
Satoshi Yamamura
KA
Kenichi Akashi
Abstract
1 min read
Hypoxia inducible factor (HIF)-1 plays an important role in cellular adaptation to hypoxia by activating oxygen-regulated genes such as vascular endothelial growth factor (VEGF) and erythropoietin. Sputum VEGF levels are reported to be decreased in COPD, despite hypoxia. Here we show that patients with COPD fail to induce HIF-1α and VEGF under hypoxic condition because of a reduction in histone deacetylase (HDAC) 7.
Catherine E. Charron, Pai-Chien Chou, David J.C. Coutts, Vaibhav Kumar, Masako To, Kenichi Akashi, Liao Pinhu, Mark Griffiths, Ian M. Adcock, Peter J Barnes, Kazuhiro Ito
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