Malaria is declining in many parts of the tropical world as a result of increased provision of effective control interventions (mainly insecticide-treated bed nets and artemisinin-based combination therapies).1 The effects on the clinical epidemiology of malaria differ depending on the level of transmission intensity. Where the transmission intensity was previously low, mortality and case numbers have declined even more, making elimination of malaria at the local and regional levels increasingly possible. Where the transmission intensity was high, the consequences are more complex, reflecting the interplay between malaria transmission and an imperfect acquired immunity. There are places in Africa where a . . .
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