Data from Does Loss of CD151 Expression Promote the Metastasis of Hypoxic Colon Cancer Cells?

<div>Abstract<p>Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.</p></div>