Critical Reading of cardiovascular trials with neutral or negative results

Claudio Rapezzi; Alberto Aimo; Iacopo Fabiani; Vincenzo Castiglione; Roberto Ferrari; Aldo Maggioni; Luigi Tavazzi

doi:10.1093/eurheartj/ehad353

Abstract

1 min read

Proposed framework for the interpretation of superiority trials with neutral or negative results.See text for details.CABANA, catheter ablation vs. antiarrhythmic drug therapy for atrial fibrillation; CASTLE-AF, catheter ablation for atrial fibrillation with heart failure; COVID-19, coronavirus disease-19; DOREMI, dobutamine compared with milrinone; FLOWER-MI, flow evaluation to guide revascularization in multivessel ST-elevation myocardial infarction; FU, follow-up; GUIDE-HF, haemodynamic-GUIDEd management of heart failure; LIFE, LCZ696 in advanced heart failure; OVERTURE, Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events; PARAGON-HF, prospective comparison of ARNI with ARB global outcomes in HF with preserved ejection fraction; PROACTIVE, PROspective pioglitAzone Clinical Trial In macroVascular Events; RED-HF, reduction of events by

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