Cortical and subcortical structural alterations in obsessive-compulsive disorder: relationships between morphology and clinical profiles in the Global OCD study

This study identified structural changes associated with illness severity, OC symptom dimensionality, and comorbidities. Our results emphasize the role of the OFC and insula in OCD and suggest comorbidity-specific alterations. The absence of case-control differences may stem from the inclusion of medication-free individuals and clinical heterogeneity within the OCD group.