Copper‐Mediated Fluorination of Aryl Trisiloxanes with Nucleophilic Fluoride

Abstract A method for the nucleophilic fluorination of heptamethyl aryl trisiloxanes to form fluoroarenes is reported. The reaction proceeds in the presence of Cu(OTf) 2 and KHF 2 as the fluoride source under mild conditions for a broad range of heptamethyltrisiloxyarenes with high functional group tolerance. The combination of this method with the silylation of aryl C−H bonds enables the regioselective fluorination of non‐activated arenes controlled by steric effects following a two‐step protocol.