RC bipolar I patients showed major initial differences and more rapid initial clinical changes, especially toward depression, with less favorable long-term outcomes than non-RC cases during treatment with olanzapine. Inclusion of RC bipolar disorder patients can complicate therapeutic trials, but these patients require further study for differential responsiveness to innovative treatments with methods of assessing clinical response that take their mood instability into account.
Eduard Vieta, José Sánchez‐Moreno, José Manuel Goikolea, Francesc Colom, Anabel Martínez‐Arán, Antonio Benabarre, Bàrbara Corbella, Carla Torrent, Mercé Comes, María Reinares, Esteve Brugué
Maria Antonietta Furio, Dina Popović, Eduard Vieta, Yelena Stukalin, Michal Hagin, Carla Torrent, Jean‐Michel Azorin, Jules Angst, Charles L. Bowden, Sergey Mosolov, Allan H. Young, Giulio Perugi
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