Comparison of Large Versus Smaller Randomized Trials for Mental Health-Related Interventions

Despina G. Contopoulos‐Ioannidis; Simon Gilbody; Thomas A Trikalinos; Rachel Churchill; Kristian Wahlbeck; John P A Ioannidis

doi:10.1176/appi.ajp.162.3.578

Abstract

1 min read

Large trials are uncommon in mental health. Their results are usually comparable with the results of smaller studies, but major disagreements do occur. Both large and smaller trials should be scrutinized as they offer a continuum of randomized evidence.

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