Common Genetic Variation at the Endothelial Nitric Oxide Synthase Locus and Relations to Brachial Artery Vasodilator Function in the Community — Sekar Kathiresan (2005) | RDL Network
Common Genetic Variation at the Endothelial Nitric Oxide Synthase Locus and Relations to Brachial Artery Vasodilator Function in the Community
Article 2005 en
Authors
SK
Sekar Kathiresan
ML
Martin G. Larson
RV
Ramachandran S. Vasan
Abstract
1 min read
A parsimonious set of SNPs captures common genetic variation at the NOS3 locus. A conservative interpretation of our results is that, accounting for multiple testing, we did not observe statistically significant relations between NOS3 sequence variants and endothelial function measures in either sex. The nominal associations of select NOS3 variants with endothelial function in men (unadjusted for multiple testing) should be viewed as hypothesis-generating observations and may merit testing in other cohorts and experimental designs.
Gary F. Mitchell, Chao‐Yu Guo, Sekar Kathiresan, Ramachandran S. Vasan, Martin G. Larson, Joseph A. Vita, Michelle J. Keyes, Mitul Vyas, Christopher Newton‐Cheh, Stacy L. Musone, Amy L. Camargo, Jared A. Drake, Daniel Levy, Christopher J. O’Donnell, Joel N. Hirschhorn, Emelia Benjamin
Bernd Wolfarth, M. Ducke, Jean Gagnon, Marie‐Christine Chagnon, L. P russe, M. R. Boulay, Miguel A. Rivera, Rainer Rauramaa, J. Stray‐Gundersen, J. Keul, Claude Bouchard
Ramachandran S. Vasan, Martin G. Larson, Jayashri Aragam, Thomas J. Wang, Gary F. Mitchell, Sekar Kathiresan, Christopher Newton‐Cheh, Joseph A. Vita, Michelle J. Keyes, Christopher J. O’Donnell, Daniel Levy, Emelia Benjamin
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