This article was written at the invitation of the Editor, in response to the preceding article by Strother et aI. (1995). I have taken this opportunity to comment on several issues, some of which have been the subject of recent exchanges (e.g. , Taylor et aI., 1993; Worsley et aI. , 1993). Others deserve mention because they have become of special cur rent interest. An overview of the development of statistical analysis in functional imaging is pre sented, followed by a discussion of some key areas.
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