Clinical significance of joint detection of mALB and NAG for early kidney damage in burn patients

BACKGROUND The aim of this study was to study the clinical significance of joint detection of mALB and NAG in early kidney damage in burn patients. METHODS Forty-five burn patients of different degrees were selected and divided into mild, moderate, severe, and heavy burns, and normal healthy controls according to their severity. Their b2- macroglobulin (b2-MG), a1-macroglobulin (a1-MG), mALB and N-acetyl-b-D-NAG were tested for 3 days, 1 week, 2 weeks, 4 weeks after the burn, respectively. RESULTS The urine concentration change b2-MG, a1-MG, MALB, and NAG are related to the area, depth and degree of the burn. The more serious the burn is, the higher the levels of mALB and NAG (P<0.001 or P<0.01) is. CONCLUSIONS Early detection of mALB and NAG is helpful for early kidney damage diagnosis in burn patients to prevent further complications.