Clinical Profile and Prognostic Significance of Natriuretic Peptide Trajectory Following Hospitalization for Worsening Chronic Heart Failure: Findings from the ASTRONAUT Trial — Stephen J. Greene (2015) | RDL Network
Clinical Profile and Prognostic Significance of Natriuretic Peptide Trajectory Following Hospitalization for Worsening Chronic Heart Failure: Findings from the ASTRONAUT Trial
In this cohort of HHF patients with reduced EF, early post-discharge NT-proBNP trajectory was associated with a distinct clinical profile and carried independent prognostic value after adjustment for patient characteristics and absolute NT-proBNP level. Future prospective study of serial NT-proBNP measurement during the hospital and early post-discharge periods is warranted to validate these findings and evaluate post-discharge NT-proBNP trajectory as a therapeutic target.
Stephen J. Greene, Gregg C. Fonarow, Scott D. Solomon, Haris Subačius, Andrew P. Ambrosy, Muthiah Vaduganathan, Aldo Maggioni, Michael Böhm, Eldrin F. Lewis, Faı̈ez Zannad, Javed Butler, Mihai Gheorghiade
Aldo Maggioni, Sally Greene, Gregg C. Fonarow, Michael Böhm, Faı̈ez Zannad, Scott D. Solomon, E. F. Lewis, Fabio Baschiera, Tien Hua, Claudio Gimpelewicz, Anastasia Lesogor, Mihai Gheorghiade, S. Ramos, Antoni Bayés de Luna, Santiago Miriuka, Maria Canto Diez, Enrico Perna, Hugo A Luquez, J. G. Pinna, Jorge Castagnino, Pedro Alvarenga, Joaquı́n Ibáñez,
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