Summary Circulating catecholamines are not abnormally elevated in asthmatics. The normal circadian fall in circulating adrenaline at night may contribute to nocturnal wheezing by facilitating release of bronchoconstrictor mast cell mediators. Asthmatics who develop exercise‐induced wheezing show an impaired catecholamine response to exercise which may facilitate mediator release during exercise. Endogenous catecholamines in asthma may therefore play a modulatory role on the release of mast cell mediators.
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