Chronic granulomatous disease and acute neutrophilic dermatosis

Lyon; Christopher Em Griffiths

doi:10.1046/j.1365-2230.1999.00503.x

Abstract

1 min read

Chronic granulomatous disease is an inherited disorder characterized by defective oxidative killing by neutrophils and other phagocytes. This results in susceptibility to persistent and life-threatening infections. We describe a 25-year-old man with chronic granulomatous disease who presented with an acute, febrile neutrophilic dermatosis. This indicates that normal neutrophil intracellular killing mechanisms are not essential in the pathogenesis of neutrophilic dermatoses.

Related publications

Article1994

The Histopathologic Spectrum of Palisaded Neutrophilic and Granulomatous Dermatitis in Patients With Collagen Vascular Disease

Paul Kim Ho Chu

Article2018

Direct Inhibitory Effect of the PDE4 Inhibitor Roflumilast on Neutrophil Migration in Chronic Obstructive Pulmonary Disease

Amy E. Dunne, Theerasuk Kawamatawong, Peter Fenwick, Ceri Davies, Hannah Tullett, Peter J Barnes, Louise Donnelly

Article2011

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

Sarah R. Walmsley, Edwin R. Chilvers, A. A. Roger Thompson, Kathryn Vaughan, Helen M. Marriott, Lisa C. Parker, Gary S. Shaw, Selina Parmar, Martin Schneider, Ian Sabroe, David H. Dockrell, Marta Milo, Cormac T. Taylor, Randall S. Johnson, Christopher W. Pugh, Peter J. Ratcliffe, Patrick H. Maxwell, Peter Carmeliet, Moira K. B. Whyte

Article2017

Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages

Martin A. Bewley, Julie A. Preston, Mohammed Mohasin, Helen M. Marriott, Richard C. Budd, Julie Swales, Paul Collini, David R. Greaves, Ruth W. Craig, Christopher E. Brightling, Louise Donnelly, Peter J Barnes, Dave Singh, Steven D. Shapiro, Moira K. B. Whyte, David H. Dockrell

Corrigendum2021

Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis

Pranvera Sadiku, Joseph Willson, Eilíse M. Ryan, David Sammut, Patrícia Coelho, Emily Watts, Robert Grecian, Jason M. Young, Martin A. Bewley, Simone Arienti, Ananda S. Mirchandani, Manuel A. Sánchez-García, Tyler Morrison, Ailing Zhang, Leila Reyes, Tobias Griessler, Privjyot Jheeta, Gordon Paterson, Christopher J Graham, John P. Thomson, J. Kenneth Baillie, A.A. Roger Thompson, Jessie-May Morgan, Abel Acosta‐Sanchez, ,