Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment

(Cell Reports 18, 1946–1957; February 21, 2017) In the originally published version of this article, the NANOG blot in Figure 5E was inadvertently included in Figure 5D. Likewise, the NANOG blot in Figure S5E was inadvertently included in Figure S5D. The corrected versions of the figures are provided here. Neither the initial errors nor the corrections alter the paper’s conclusions. The authors regret the errors.Figure S5Related to Figure 5View Large Image Figure ViewerDownload Hi-res image Download (PPT) Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell EnrichmentLu et al.Cell ReportsFebruary 21, 2017In BriefLu et al. report that exposure of breast cancer cells to chemotherapy induces HIF-dependent expression of GSTO1, which interacts with RYR1 to increase intracellular Ca2+ levels and trigger PYK2 → SRC → STAT3 signaling leading to breast cancer stem cell enrichment. GSTO1 knockdown blocks cancer stem cell enrichment, tumor initiation, and metastasis. Full-Text PDF Open Access