Chemo-enzymatic Synthesis of 3-Deoxy-β-<scp>D</scp>-ribofuranosyl Purines and Study of Their Biological Properties
Article 2003 en
Authors
VB
V. N. Barai
АЗ
А. И. Зинченко
LE
L. A. Eroshevskaya
Abstract
1 min read
9-(3-Deoxy-beta-D-erythro-pentofuranosyl)-2,6-diaminopurine (2) was synthesized by an enzymatic transglycosylation of 2,6-diaminopurine using 3'-deoxycytidine (1) as a donor of the sugar moiety. Nucleoside 2 was transformed to 3'-deoxy guanosine (3), 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-2-amino-6-oxopurine (3'-deoxyisoguanosine; 4), and 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-2-fluoroadenine (5). Compounds 2-5 were evaluated for their anti-HIV activity.
Ivan I. Fedorov, E. M. KAZ'MINA, G. V. Gurskaya, Maxim V. Jasko, Valery E. Zavodnic, Jan Balzarini, De Clercq Erik, Abdesslem Faraj, Jean‐Pierre Sommadossi, Jean‐Louis Imbach, Gilles Gosselin
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