ChemInform Abstract: Nucleotides. Part 32. Synthesis of 2′‐5′ Connected Oligonucleotides. Prodrugs for Antiviral and Antitumoral Nucleosides.

Piet Herdewijn; Ramamurthy Charubala; De Clercq Erik; Wolfgang Pfleiderer

doi:10.1002/chin.199011317

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ChemInform Abstract: Nucleotides. Part 32. Synthesis of 2′‐5′ Connected Oligonucleotides. Prodrugs for Antiviral and Antitumoral Nucleosides.

Article 1990 en

Abstract

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Abstract Coupling of cytotoxically and antivirally active nucleosides with diadenylates by the phosphotriester approach leads to the title prodrugs, e.g. (I) and (II).

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