Chemical reactions, enzyme catalysts, and stable isotopes

A corollary to this law shows how the chemical equilibrium varies with temperature – namely, how, as the temperature increases, more of the one compound is formed at the expense of the other, or vice versa. This corollary can be stated as follows: At low temperature the greater yield is always of that product whose formation is accompanied by evolution of heat.Jacobus H. van’t Hoff, Nobel Prize Lecture, 1901