We thank Blackwell et al 1 for raising an important question about the classification of depression in a population of IBD patients in the UK. In our study,examining depression as a risk factor for the development of IBD,2 we chose to use a more restrictive case definition of depression based closely on a definition of major depressive disorder (MDD) as a clinically significant form of depression recognised in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)3 and known to be associated with a significant degree of morbidity and mortality.4 5 In …
Stephen M. Stahl, Debbi Ann Morrissette, Gianni L. Faedda, Maurizio Fava, Joseph F. Goldberg, Paul E. Keck, Yena Lee, Gin S. Malhi, Ciro Marangoni, Susan L. McElroy, Michael J. Ostacher, Joshua D. Rosenblat, Eva Solé, Trisha Suppes, Minoru Takeshima, Michael E. Thase, Eduard Vieta, Allan H. Young, Mark Zimmerman, Roger S. McIntyre
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