Cell-Selective Inhibition of NF-κB Signaling Improves Therapeutic Index in a Melanoma Chemotherapy Model

Thomas Enzler; Yasuyo Sano; Min‐Kyung Choo; Howard B. Cottam; Michael Karin; Hensin Tsao; Jin Mo Park

doi:10.1158/2159-8290.cd-11-0143

Abstract

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Our findings show that the IκB kinase–NF-κB signaling pathway is important for both promoting treatment resistance and preventing host toxicity in cancer chemotherapy; however, the two functions are exerted by distinct cell type–specific mechanisms and can therefore be selectively targeted to achieve an improved therapeutic outcome.

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Cell-Selective Inhibition of NF-κB Signaling Improves Therapeutic Index in a Melanoma Chemotherapy Model

Abstract

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Data from Cell-Selective Inhibition of NF-κB Signaling Improves Therapeutic Index in a Melanoma Chemotherapy Model

Data from Cell-Selective Inhibition of NF-κB Signaling Improves Therapeutic Index in a Melanoma Chemotherapy Model

TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer

Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy

Targeting NF-κB signaling pathway in cancer by dietary polyphenols