Caspase-independent commitment phase to apoptosis in activated blood T lymphocytes: reversibility at low apoptotic insult

Céline Dumont; Antoine Dürrbach; Nicolas Bidère; Matthieu Rouleau; Guido Guido Kroemer; Ghislaine Bernard; François Hirsch; Bernard Charpentier; Santos A. Susín; A Senik

doi:10.1182/blood.v96.3.1030

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Caspase-independent commitment phase to apoptosis in activated blood T lymphocytes: reversibility at low apoptotic insult

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Caspase-independent commitment phase to apoptosis in activated blood T lymphocytes: reversibility at low apoptotic insult

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4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG