Caspase 1–independent activation of interleukin‐1β in neutrophil‐predominant inflammation
Article 2009 en
Authors
MG
Mónica Gumà
LR
Lisa Ronacher
RL
Ru Liu‐Bryan
Abstract
1 min read
The production of IL-1beta by neutrophils and mast cells is not exclusively dependent on caspase 1, and other proteases can compensate for the loss of caspase 1 in vivo. These pathways might therefore compromise the caspase 1-targeted therapies in neutrophil-predominant arthritis.
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