The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting inflammation.
Zhenyu Zhong, Atsushi Umemura, Elsa Sánchez‐López, Shuang Liang, Shabnam Shalapour, Jerry Wong, Feng He, Daniela Boassa, Guy Perkins, Syed R. Ali, Matthew G McGeough, Mark H. Ellisman, Ekihiro Seki, Åsa B. Gustafsson, Hal M. Hoffman, María T. Díaz‐Meco, Jorge Moscat, Michael Karin
Hongxu Xian, Kosuke Watari, Elsa Sánchez‐López, Joseph Offenberger, Janset Onyuru, Harini Sampath, Wei Ying, Hal M. Hoffman, Gerald S. Shadel, Michael Karin
Luigi Franchi, Tatjana Eigenbrod, Raúl Muñoz-Planillo, Ulas Ozkurede, Yun-Gi Kim, Arindam Chakrabarti, Michael Gale, Robert H. Silverman, Marco Colonna, Akira Shizuo, Gabriel Núñez
.jpg){kind=small}
Discussion(0)
No comments yet. Be the first to comment.