Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?

Kristian Thorlund; P.J. Devereaux; Jørn Wetterslev; Gordon Guyatt; John P A Ioannidis; Lehana Thabane; Lise Lotte Gluud; Bodil Als‐Nielsen; Christian Gluud

doi:10.1093/ije/dyn179

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Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?

Article 2008 en

Abstract

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Evaluating statistical inference with trial sequential monitoring boundaries when meta-analyses fall short of a required IS may reduce the risk of false positive results and important inaccurate effect estimates.

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