C-39 | Comparative Outcomes of Percutaneous Coronary Interventions in Patients with Chronic Total Occlusions: The Impact of Active Cancer

Percutaneous coronary interventions (PCI) for chronic total occlusions (CTO) present unique challenges, especially in patients with active cancer due to their complex health profiles. This study aims to fill the gap in knowledge regarding outcomes of CTO PCI in cancer populations, focusing on in-hospital mortality and readmission rates. Data from the National Inpatient Sample (2016-2020) were analyzed to identify patients diagnosed with CTO who underwent PCI, categorizing them into active cancer and non-cancer groups. Multivariate regression analysis determined the impact of cancer on in-hospital mortality (primary outcome) and readmission rates (secondary outcome). As delineated in Table I, patients with active cancer were generally older (72 vs. 66 years, p = 0.001) and had a distinct profile of comorbidities compared to non-cancer patients. In-hospital mortality was slightly higher in the cancer group (1.3% vs. 0.8%, p = 0.33), and readmission rates were notably increased (9.3% vs. 7.1%, p = 0.05). Secondary outcomes (Table II) revealed differences in post-procedural complications, acute kidney injury, and length of stay between the two cohorts. Patients with active cancer undergoing CTO PCI exhibit marginally higher in-hospital mortality and significantly higher readmission rates compared to those without cancer. These findings underscore the need for specialized care strategies management in this high-risk group to improve outcomes. Further studies are warranted to refine patient care protocols and enhance overall treatment outcomes for this vulnerable population.