Brx Mediates the Response of Lymphocytes to Osmotic Stress Through the Activation of NFAT5

Tomoshige Kino; Hiroaki Takatori; Irini Manoli; Yonghong Wang; Anatoly Tiulpakov; Marc R. Blackman; Yan Su; George Chrousos; Alan H. DeCherney; James H. Segars

doi:10.1126/scisignal.2000081

Abstract

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The guanine nucleotide exchange factor Brx is essential for osmotic stress–mediated expression of nfat5 in lymphocytes.

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