Brain reserve and cognitive reserve protect against cognitive decline over 4.5 years in MS

James Sumowski; Maria A. Rocca; Victoria M. Leavitt; Jelena Dačković; Šarlota Mesaroš; Jelena Drulović; John DeLuca; Massimo Filippi

doi:10.1212/wnl.0000000000000433

Abstract

1 min read

We provide longitudinal support for theories of brain reserve and cognitive reserve in MS. Larger MLBG protects against decline in cognitive efficiency, and greater intellectual enrichment protects against decline in cognitive efficiency and memory. Consideration of these protective factors should improve prediction of future cognitive decline in patients with MS.

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