Brain reserve against physical disability progression over 5 years in multiple sclerosis

James Sumowski; Maria A. Rocca; Victoria M. Leavitt; Alessandro Meani; Šarlota Mesaroš; Jelena Drulović; Paolo Preziosa; Christian Habeck; Massimo Filippi

doi:10.1212/wnl.0000000000002702

Abstract

1 min read

Larger MLBG was linked to lower risk for disability progression in patients with MS over 5 years, which is the first extension of the brain reserve hypothesis to physical disability. MLBG (ICV) represents a clinically available metric that may help gauge risk for future disability in patients with MS, which may advance the science and practice of early intervention. Potential avenues for future research are discussed.

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