Brain Aging in Specific Phobia: An ENIGMA-Anxiety Mega-Analysis

Kimberly V. Blake; Kevin Hilbert; Jonathan Ipser; Laura K. M. Han; Janna Marie Bas‐Hoogendam; Fredrik Åhs; Jochen Bauer; Katja Beesdo‐Baum; Johannes Björkstrand; Laura Blanco‐Hinojo; Joscha Böhnlein; Robin Bülow; Marta Cano; Narcı́s Cardoner; Xavier Caseras; Udo Dannlowski; Mats Fredrikson; Liesbet Goossens; Hans J. Grabe; Dominik Grotegerd; Tim Hahn; Alfons O. Hamm; Ingmar Heinig; Martin J. Herrmann; D. J. Hofmann; Hamidreza Jamalabadi; Andreas Jansen; Merel Kindt; Tilo Kircher; Anna Luisa Klahn; Katja Koelkebeck; Axel Krug; Elisabeth J. Leehr; Martín Lotze; Jürgen Margraf; Markus Muehlhan; Igor Nenadić; Wenceslao Peñate Castro; Andre Pittig; Jens Plag; Jesús Pujol; Jan Richter; Isabelle C. Ridderbusch; Francisco Rivero; Axel Schäfer; Judith Schäfer; Anne Schienle; Elisabeth Schrammen; Koen Schruers; Esther Seidl; Rudolf Stark; Benjamin Straube; Thomas Straube; Andreas Ströhle; Lea Teutenberg; Sophia I. Thomopoulos; Carlos Ventura‐Bort; Renée M. Visser; Henry Völzke; Albert Wabnegger; Julia Wendt; Hans‐Ulrich Wïttchen; Katharina Wittfeld; Yunbo Yang; Anna Zilverstand; Peter Zwanzger; Lianne Schmaal; Moji Aghajani; Daniel S. Pine; Paul M. Thompson; Nic J.A. van der Wee; Dan Joseph Stein; Ulrike Lueken; Nynke A. Groenewold

doi:10.1101/2025.03.19.25323474

Abstract

1 min read

Brain aging did not relate to SPH in the full sample. However, a diagnosis-by-age interaction was observed across analyses, and was strongest in formally diagnosed SPH. Post-hoc analyses showed a subtle advanced brain aging in young adults with formally diagnosed SPH. Taken together, these findings indicate the importance of clinical severity, impairment and persistence, and may suggest a slightly earlier end to maturational processes or subtle decline of brain structure in SPH.

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