Bone Marrow Osteoblastic Niche: A New Model to Study Physiological Regulation of Megakaryopoiesis
Article 2009 en
Authors
IP
Isabella Pallotta
ML
Michael L. Lovett
WR
William L. Rice
Abstract
1 min read
The mechanism by which megakaryocytes (Mks) proliferate, differentiate, and release platelets into circulation are not well understood. Growing evidence indicates that a complex regulatory mechanism, involving cellular interactions, composition of the extracellular matrix and physical parameters such as oxygen tension, may contribute to the quiescent or permissive microenvironment related to Mk differentiation and maturation within the bone marrow.
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