Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry — Kharis Burns (2024) | RDL Network
Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry
Article 2024 en
Authors
KB
Kharis Burns
BM
Benjamin H. Mullin
LM
Loes M E Moolhuijsen
Abstract
1 min read
Polycystic ovary syndrome (PCOS) is a complex multifactorial disorder with a substantial genetic component. However, the clinical manifestations of PCOS are heterogeneous with notable differences between lean and obese women, implying a different pathophysiology manifesting in differential body mass index (BMI). We performed a meta-analysis of genome-wide association study (GWAS) data from six well-characterised cohorts, using a case-control study design stratified by BMI, aiming to identify genetic variants associated with lean and overweight/obese PCOS subtypes.
Felix R. Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Mägi, Richa Saxena, Triin Laisk-Podar, Margrit Urbanek, M. Geoffrey Hayes, Guðmar Þorleifsson, Juan Fernández‐Tajes, Anubha Mahajan, Benjamin H. Mullin, Bronwyn Stuckey, Timothy D. Spector, Scott G. Wilson, Mark O. Goodarzi, Lea K. Davis, Barbara Obermeyer-Pietsch, André G. Uitterlinden, Verneri Anttila, Benjamin M. Neale, Paul M Ridker, Bart Fauser, Irina Kowalska, Jenny A. Visser, Marianne Anderson, Ken K. Ong, Elisabet Stener‐Victorin, David A. Ehrmann, Richard S. Legro, Andres Salumets, Mark I. McCarthy, Laure Morin‐Papunen, Unnur Þorsteinsdóttir, Kāri Stefánsson, Unnur Styrkársdóttir, John R. B. Perry, Andrea Dunaif, Joop S.E. Laven, Steve Franks, Cecilia M. Lindgren, Corrine K. Welt
Felix R. Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Mägi, Richa Saxena, Triin Laisk, Margrit Urbanek, M. Geoffrey Hayes, Guðmar Þorleifsson, Juan Fernández‐Tajes, Anubha Mahajan, Benjamin H. Mullin, Bronwyn Stuckey, Timothy D. Spector, Scott G. Wilson, Mark O. Goodarzi,
Yoonjung Yoonie Joo, Ky’Era V. Actkins, Jennifer A. Pacheco, Anna O. Basile, Robert J. Carroll, David R. Crosslin, Felix R. Day, Joshua C. Denny, Digna R. Velez Edwards, Hákon Hákonarson, John B. Harley, Scott J. Hebbring, Kevin Ho, Gail P. Jarvik, Michelle R. Jones, Tugce Karaderi, Frank Mentch, Cindy Meun, Bahram Namjou, Sarah A. Pendergrass, Marylyn D. Ritchie, Ian B. Stanaway, Margrit Urbanek, ,
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