Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort

Marco Matejcic; Jordi de Batlle; Cristian Ricci; Carine Biessy; Flavie Perrier; Inge Huybrechts; Elisabete Weiderpass; Marie‐Christine Boutron‐Ruault; Claire Cadeau; Mathilde His; David G. Cox; Heiner Boeing; Renée T. Fortner; Rudolf Kaaks; P. Lagiou; Antonia Trichopoulou; Vassiliki Benetou; ­Rosario ­Tumino; Salvatore Panico; Sabina Sieri; Domenico Palli; Fulvio Ricceri; H. Bas Bueno-de-Mesquita; Guri Skeie; Pilar Amiano; María‐José Sánchez; M.D. Chirlaque; Aurelio Barricarte; J.R. Quirós; Genevieve Buckland; Carla H. van Gils; P H M Peeters; Timothy J. Key; Elio Riboli; Björn Gylling; Anne Zeleniuch‐Jacquotte; Marc J. Gunter; Isabelle Romieu; Véronique Chajès

doi:10.1002/ijc.30536

Abstract

1 min read

Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (ORQ4-Q1 = 1.26; 95% CI 1.00-1.58; Ptrend = 0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4-Q1 = 1.29; 95% CI 1.02-1.62; Ptrend = 0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation.

Related publications

Article2017

B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Santé Cohort

Manon Egnell, Philippine Fassier, Lucie Lécuyer, Laurent Zelek, Marie‐Paule Vasson, Serge Hercberg, Paule Latino‐Martel, Pilar Galán, Mélanie Deschasaux, Mathilde Touvier

Article2016

Circulating Folate and Vitamin B12 and Risk of Prostate Cancer: A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 Controls

Alison Price, Ruth C. Travis, Paul N. Appleby, Demetrius Albanes, Aurelio Barricarte Gurrea, Tone Bjørge, H. Bas Bueno-de-Mesquita, Chu Chen, Jenny Donovan, Randi E. Gislefoss, Gary Goodman, Marc J. Gunter, Freddie C. Hamdy, Mattias Johansson, Irena B. King, Tilman Küehn, Satu Männistö, Richard M. Martin, Klaus Meyer, David E. Neal, Marian L. Neuhouser, Ottar Nygård, Pär Stattin, Grethe S. Tell, Antonia Trichopoulou, Rosario Tumino, Per Magne Ueland, Arve Ulvik, Stefan de Vogel, Dan Joseph Stein, Stephanie J. Weinstein, Timothy J. Key, Naomi E. Allen

Article2017

Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort

Danja Sarink, Helena Schöck, Theron Johnson, Kim Overvad, Marianne Holm, Anne Tjønneland, Marie‐Christine Boutron‐Ruault, Mathilde His, Marina Kvaskoff, Heiner Boeing, Παγώνα Λάγιου, Eleni‐Maria Papatesta, Antonia Trichopoulou, Domenico Palli, Valeria Pala, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, H. B. Bueno-de-Mesquita, Carla H. van Gils, Petra H. Peeters, Elisabete Weiderpass, Antonio Agudo, María‐José Sánchez,

Article2018

Abstract P5-12-02: B-vitamin intake from diet and supplements and breast cancer risk in middle-aged women: Results from the prospective NutriNet-Santé cohort

Manon Egnell, Philippine Fassier, Lucie Lécuyer, Laurent Zelek, M-P Vasson, Serge Hercberg, Paule Latino‐Martel, Pilar Galán, Mélanie Deschasaux, M Touvier

Preprint2023

Data from Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort

Danja Sarink, Helena Schöck, Theron Johnson, Kim Overvad, Marianne Holm, Anne Tjønneland, Marie‐Christine Boutron‐Ruault, Mathilde His, Marina Kvaskoff, Heiner Boeing, Παγώνα Λάγιου, Eleni‐Maria Papatesta, Antonia Trichopoulou, Domenico Palli, Valeria Pala, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, H. Bas Bueno‐de‐Mesquita, Carla H. van Gils, Petra H.M. Peeters, Elisabete Weiderpass, Antonio Agudo, ,