Biological evaluation of 1,2,3‐triazole‐based polymers for potential applications as hard tissue material

This contribution deals with the synthesis and subsequent bulk polymerization of multifunctional electron-deficient internal alkynes with several multifunctional azides in a metal-free 1,3-dipolar azide–alkyne cycloaddition. The biocompatibility of alkynes, azides, and resulting networks was investigated in a cell biological study. All monomers revealed distinctive concentration-dependent cytotoxic properties. These harmful side effects on the cell integrity were completely diminished after polymerization of the educts resulting in materials with highly biocompatible properties. Additional Supporting Information may be found in the online version of this article. Supplementary Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.