Nanomedicine on the basis of aggregated-induced emission (AIE) luminogens with exceptional potency is growing into a sparkling frontier in fluorescence imaging and phototheranostics. Of particular interest is biomimetic AIE nanomedicine comprised by AIE luminogens and biocarrier, which represents a win-win integration and are recently developed at a tremendous pace, mainly benefiting from the intrinsic advantages including enhanced biocompatibility, prolonged circulation time, specific targeting ability, immune activation, and supremely extraordinary phototheranostic outputs. In view of the inexhaustible and vigorous vitality in the field, this review provides an integrated picture on biomimetic AIE nanomedicine involving the basic concepts, significant breakthroughs, and recent trends. In addition, based on the current achievements, some critical challenges and perspectives are also discussed.
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