Bicyclic Nucleoside Inhibitors of Varicella-Zoster Virus: Synthesis and Biological Evaluation of 2′,3′-Dideoxy- 3′-fluoro and 2′-Deoxy-xylo Derivatives

Bicyclic furano pyrimidine analogues have been shown to be potent and selective inhibitors of varicella-zoster virus (VZV). Our initial compounds bearing a C8-C10 side chain showed ca 300-fold incr...