Ghana is a West African country for which apparently there are limited scientometric studies. The objective of this study was to analyze the Ghanaian contribution to knowledge captured in the Thomson Reuters Science Citation Index Expanded (SCI-EXPANDED) database from 1936 - 2016. The following data were analyzed: document type, the language of publication, publication trend, Web of Science Subject Categories, Journals, international collaboration, institutions, authors, and highly cited articles. Indicators such as the total number of articles, first author articles, and corresponding author articles were applied to compare publication performance for collaborative countries and institutions. Also, number of single institute articles: number of nationally collaborative articles: number of internationally collaborative articles (S : N : I) were also used to compare publication characteristics of institutions in Ghana. Results showed that publication trend increased from 1998 to 2015, with researches focusing on health and medicine. PLoS One was the top productive journal, and the most collaborative country for Ghana articles was the USA. Contributions from the University of Ghana were ranked the top one institution for Ghana articles, and higher citation papers were found in international collaborations. In conclusion, the contribution to knowledge of Ghanaian authors is massive in the areas of public, environmental and occupational health and tropical medicine but the impact factor is higher for immunology, infectious diseases, and microbiology articles. Therefore, Ghanaian authors are encouraged to publish more articles in high impact factor journals with Thomson Reuters Scientific indexing in order to have their researches recognized by the existing international databases.
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