BENZYL-FUNCTIONALIZED<i>cyclo</i>Sal-d4T MONOPHOSPHATES

Jürgen Renze; Martin Plath; Christian Ducho; Jan Balzarini; De Clercq Erik; Chris Meier

doi:10.1081/ncn-100002461

Abstract

1 min read

Synthetic routes to benzyl-functionalized cycloSal-d4T monophosphates (7CH2X-cycloSal-d4TMP) have been developed. Their hydrolytic behavior in basic aqueous solution (pH = 7.3) was studied and their hydrolysis half-lives were determined. It turned out that two different degradation pathways are leading to different products: beside the formation of the expected d4TMP and a styrene type derivative, a phenyl-d4T-phosphodiester was obtained as well. The product distribution was specified.

Discussion(0)

No comments yet. Be the first to comment.

BENZYL-FUNCTIONALIZED<i>cyclo</i>Sal-d4T MONOPHOSPHATES

Abstract

Discussion(0)

Related publications

Comparative Study of Bis(Benzyl)Phosphate Triesters of 2′,3′-Dideoxy-2′,3′-Didehydrothymidine (d4T) and<i>Cyclo</i>Sal-d4TMP — Hydrolysis, Mechanistic Insights and Anti-HIV Activity

d4TMP Delivery from 7-Substituted<i>cyclo</i>Sal-d4TMPs

Study of Different Substituted Cyclic and Acyclic Benzylpronucleotides of d4T Relative to Their Hydrolytic Stability and Antiviral Activity

<i>cyclo</i>Sal-2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine Monophosphate (<i>cyclo</i>Sal-d4TMP): Synthesis and Antiviral Evaluation of a New d4TMP Delivery System

Aryl-Substituted and Benzo-Annulated<i>Cyclo</i>Sal-Derivatives of 2′,3′-Dideoxy-2′,3′-Didehydrothymidine Monophosphate — Correlation of Structure, Hydrolysis Properties and Anti-HIV Activity

Related publications

Article2002
Comparative Study of Bis(Benzyl)Phosphate Triesters of 2′,3′-Dideoxy-2′,3′-Didehydrothymidine (d4T) and<i>Cyclo</i>Sal-d4TMP — Hydrolysis, Mechanistic Insights and Anti-HIV Activity
Article2002

Article2003
d4TMP Delivery from 7-Substituted<i>cyclo</i>Sal-d4TMPs
Article2003

Article2003
Study of Different Substituted Cyclic and Acyclic Benzylpronucleotides of d4T Relative to Their Hydrolytic Stability and Antiviral Activity
Article2003

Article1998
<i>cyclo</i>Sal-2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine Monophosphate (<i>cyclo</i>Sal-d4TMP): Synthesis and Antiviral Evaluation of a New d4TMP Delivery System
Article1998

Article2002
Aryl-Substituted and Benzo-Annulated<i>Cyclo</i>Sal-Derivatives of 2′,3′-Dideoxy-2′,3′-Didehydrothymidine Monophosphate — Correlation of Structure, Hydrolysis Properties and Anti-HIV Activity
Article2002