Abstract
1 min readBacterial translocation occursinascitic cirrhotic rats,butitsassociation with ascites infection isunknown.Theaimof thisstudywas to assesstherelation betweenbacterial translocation and ascites infection incirrhotic rats.Male Sprague-Dawley ratswereinducedto cirrhosis withintragastric CC14.Ascitic fluid, portal andperipheral blood, mesentericlymphnodes,liverand spleen sampleswerecultured beforedeathin thosecirrhotic ratswithless(group A)or more (groupB) than 250 polymorphonuclear neutrophils/mm3 in ascitic fluid, aswellasinhealthy control rats. Histological examination of jejunum, ileum,andcaecumwasalsoperformed. Bacterial translocation occurred in45%of ascitic rats(without differences between groupsA andB),butin0% controls (p=0.01). Bacterial translocation was associated withpositive ascitic fluid culture in60%ofthecases. Inallofthem thesamebacterial species wasisolated in bothmesenteric lymphnodeandascitic fluid. Submucosal caecal oedema(100%), ileal lymphangiectasia (410/%), andcaecal inflammatory infiltrate (41%)occurred in ascitic rats, thelastbeingassociated with ascitic fluidpositive culture(p=0.04). Theseresults suggeststhatbacterial translocation occursfrequently inascitic cirrhotic rats, andmayplayapermissive, butnotunique, partinanumberofascites infections. Whetherhistological changes seen in cirrhotic ascitic ratsfavour bacterial translocation remainsto be elucidated. (Gut1994; 35:1648-1652)
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