Axonal Injury and Overall Tissue Loss Are Not Related in Primary Progressive Multiple Sclerosis
Article 2005 en
Authors
MR
Marco Rovaris
AG
Antonio Gallo
AF
Andrea Falini
Abstract
1 min read
Axonal-neuronal damage in the brain of patients with PPMS seems to occur, at least partially, independently of the burden of magnetic resonance imaging-visible lesions. Whole-brain N-acetylaspartate values and normalized brain volumes were unrelated in this cohort, thereby suggesting that 1H-MRS and atrophy assessment may provide in vivo complementary information about the actual extent of brain damage in PPMS.
Marco Rovaris, Elda Judica, Jaume Sastre‐Garriga, Àlex Rovira, Maria Pia Sormani, Béatrice Benedetti, Tijmen Korteweg, Nicola De Stefano, Zhaleh Khaleeli, Xavier Montalbán, Frederik Barkhof, David H. Miller, Chris H. Polman, Alan J. Thompson, Massimo Filippi
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