Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma — Isabel Ben‐Batalla (2013) | RDL Network
Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma
Article 2013 en
Authors
IB
Isabel Ben‐Batalla
AS
Alexander Schultze
MW
Mark Wroblewski
Abstract
1 min read
Key Points Axl inhibition by BGB324 is active in FLT3-mutated and FLT3 wild-type AML, and presence of Axl and Gas6 are required for therapeutic efficacy. AML cells educate BMDSCs to secrete Gas6, which mediates leukemia cell proliferation and therapy resistance.
Isabel Ben‐Batalla, Alexander Schultze, Mark Wroblewski, Robert Erdmann, Michael Heuser, Kristoffer Riecken, Mascha Binder, Miguel Cubas‐Cordova, Melanie Janning, Jasmin Wellbrock, Boris Fehse, Christian Hagel, Jürgen Krauter, James B. Lorens, Arnold Ganser, Walter Fiedler, Peter Carmeliet, Klaus Pantel, Carsten Bokemeyer, Sonja Loges
Robert Erdmann, Heather G. Jørgensen, Alexander Schultze, Gunhild von Amsberg, Isabel Ben-Battala, Mark Wroblewski, Miguel Cubas Córdova, Stefanie Sawall, Victoria Witzke, Elaine Allan, Leena Mukherjee, Heather Morrison, Jennifer Cassels, Philippe Schafhausen, Nicolaus Kroeger, James B. Lorens, Richard E. Clark, Peter Vandenberghe, Tim H. Brümmendorf, Andreas Hochhaus, Peter Carmeliet, Klaus Pantel, Carsten Bokemeyer, ,
Isabel Ben‐Batalla, Robert Erdmann, Heather G. Jørgensen, Rebecca Mitchell, Thomas Ernst, Gunhild von Amsberg, Philippe Schafhausen, Janna L. Velthaus, Stephen Rankin, Richard E. Clark, Steffen Koschmieder, Alexander Schultze, Subir K. Mitra, Peter Vandenberghe, Tim H. Brümmendorf, Peter Carmeliet, Andreas Hochhaus, Klaus Pantel, Carsten Bokemeyer, G. Vignir Helgason, Tessa L. Holyoake, Sonja Loges
Isabel Ben‐Batalla, Robert G. Erdmann, Heather G. Jørgensen, Rebecca Mitchell, Thomas Ernst, Gunhild von Amsberg, Philippe Schafhausen, Janna L. Velthaus, Stephen E. Rankin, Richard E. Clark, Steffen Koschmieder, Alexander Schultze, Subir K. Mitra, Peter Vandenberghe, Tim H. Brümmendorf, Peter Carmeliet, Andreas Hochhaus, Klaus Pantel, Carsten Bokemeyer, G. Vignir Helgason, Tessa L. Holyoake, Sonja Loges
Isabel Ben‐Batalla, Robert G. Erdmann, Heather G. Jørgensen, Rebecca Mitchell, Thomas Ernst, Gunhild von Amsberg, Philippe Schafhausen, Janna L. Velthaus, Stephen E. Rankin, Richard E. Clark, Steffen Koschmieder, Alexander Schultze, Subir K. Mitra, Peter Vandenberghe, Tim H. Brümmendorf, Peter Carmeliet, Andreas Hochhaus, Klaus Pantel, Carsten Bokemeyer, G. Vignir Helgason, Tessa L. Holyoake, Sonja Loges
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