Autotaxin Inhibitor Protects from Chronic Allograft Injury in Rat Kidney Allotransplantation

Monica Cortinovis; Sistiana Aiello; Marilena Mister; Karin Conde‐Knape; Marina Noris; Rubina Novelli; Samantha Solini; Pamela Yossenaidy Rodriguez Ordonez; Ariela Benigni; Giuseppe Remuzzi

doi:10.1159/000502908

Abstract

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In summary, ATXi had protective effects on indices of chronic allograft injury and could be of therapeutic add-on value in the kidney transplant setting. Notably, an ATX inhibitor is currently being investigated in 2 large phase 3 studies in idiopathic pulmonary fibrosis, underscoring the clinical relevance of our findings.

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