Autophagy extends lifespan via vacuolar acidification

Autophagy extends lifespan via vacuolar acidification – In view of the fact that macroautophagy (hereafter described as autophagy) constitutes (one of) the major anti-aging pathway(s), we evaluated the hypothesis that methionine could act as an important and potent autophagic regulator. Indeed, we discovered that MetR induces a rapid and long-lasting increase in autophagic flux. Importantly, deletions of genes that are essential for (...)