Autophagy extends lifespan via vacuolar acidification

Christoph Ruckenstuhl; Christine Netzberger; Iryna Entfellner; Didac Carmona‐Gutiérrez; Thomas Kickenweiz; Slaven Stekovic; Christina Gleixner; Christian Schmid; Lisa Klug; Ivan Hajnal; Alice G. Sorgo; Tobias Eisenberg; Sabrina Buettner; Guillermo Mariño; Rafał Kozieł; Christoph Magnes; Frank Sinner; Thomas R. Pieber; Pidder Jansen‐Dürr; Kai-Uwe Froehlich; Guido Guido Kroemer; Frank Madeo

doi:10.15698/mic2014.05.147

Abstract

1 min read

Autophagy extends lifespan via vacuolar acidification – In view of the fact that macroautophagy (hereafter described as autophagy) constitutes (one of) the major anti-aging pathway(s), we evaluated the hypothesis that methionine could act as an important and potent autophagic regulator. Indeed, we discovered that MetR induces a rapid and long-lasting increase in autophagic flux. Importantly, deletions of genes that are essential for (...)

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