Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3

Larissa Fabritz; Dierk Damke; Markus Emmerich; Susann G. Kaufmann; Kathrin Theis; Andreas Blana; Lisa Fortmüller; Sandra Laakmann; Sven Hermann; Elena Aleynichenko; Johannes Steinfurt; Daniela Volkery; Burkhard Riemann; Uwe Kirchhefer; Michael R. Franz; Günter Breithardt; Edward Carmeliet; Michael Schäfers; Sebastian K.G. Maier; Peter Carmeliet; Paulus Kirchhof

doi:10.1093/cvr/cvq029

Abstract

1 min read

Cholinergic stimulation provokes arrhythmias in this model of LQT3 by triggering bradycardia. beta-Adrenoceptor density is reduced, and beta-adrenoceptor blockade does not prevent arrhythmias. Sodium channel blockade and beta-adrenoceptor stimulation suppress arrhythmias by shortening repolarization and minimizing difference in late sodium current.

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