Autocrine signaling of type 1 interferons in successful anticancer chemotherapy.
Article 2015 en
Authors
EV
Erika Vacchelli
AS
Antonella Sistigu
TY
Takahiro Yamazaki
Abstract
1 min read
Anthracycline-based chemotherapies are particularly effective if they succeed in reinstating immunosurveillance by the induction of immunogenic cell death (ICD) in the tumor. Recently, we discovered that ICD is coupled to the induction of type 1 interferons (IFNs-I) that act in an autocrine fashion on cancer cells, thereby increasing their immunogenic potential.
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