Asymmetric Wacker-Type Cyclization Catalyzed by Pd-SPRIX
Synfacts 2010(11): 1263-1263
Article 2010 English
Authors
HS
Hiroaki Sasai
KT
Kazuhiro Takenaka
SM
Sasankasekhar Mohanta
Abstract
1 min read
Diketones have previously been shown to undergo Wacker-type cyclizations: 5-exo-trig cyclizations lead to furan rings, and pyran rings are formed through 6-endo-trig cyclizations. The first enantioselective 6-endo-trig Wacker-type cyclization is described here, catalyzed by a palladium spiro bis(isoxazoline) (SPRIX) complex.
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