Asymmetric Palladium-Catalyzed Directed Intermolecular Fluoroarylation of Styrenes

Eric P. A. Talbot; Talita de A. Fernandes; Jeffrey M. McKenna; Dean Toste

doi:10.1021/ja412881j

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Asymmetric Palladium-Catalyzed Directed Intermolecular Fluoroarylation of Styrenes

Article 2014 en

Abstract

1 min read

A mild catalytic asymmetric direct fluoro-arylation of styrenes has been developed. The palladium-catalyzed three-component coupling of Selectfluor, a styrene and a boronic acid, provides chiral monofluorinated compounds in good yield and in high enantiomeric excess. A mechanism proceeding through a Pd(IV)-fluoride intermediate is proposed for the transformation and synthesis of an sp(3) C-F bond.

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